The seismic forces must be properly defined as required by European geotechnical design Codes. They are dependent from the morphological and stratigraphic characteristics that determine the local seismic response. The local seismic response can be evaluated using a simplified approach which is based on the classification of the subsoil according to the values of the shear wave propagation speed Vs. In the present case study, to complete the quay of the Rovigo Interport (facing the River Canal Bianco), where a not negligible load is planned to be applied (50 kPa), has been designed a foundation with a large slab founded with not pre-casted reinforced concrete piles diameter 350 mm, drilled without removing soil, with vibrating casing, for settlement reduction (rafted piles as settlement reducers), on an area of approximately 6000 m2. The subsoil in this area, from geological and geotechnical point of view, is very variable and with layers of soft clay and loose sand or silt, with no presence of a dense and uniform sand layer where to transfer loads to. Moreover, the geotechnical model was complicated because of the presence of an old diaphragm wall with anchors (whose projection in plant covers around half of area) and was designed a large underground basin for hydraulic invariance. For this reason, an extensive campaign of CPTU and DMT tests, together with Boreholes, sampling and Laboratory tests was carried out in this area, which allowed a detailed characterization of the subsoil. Through direct measurement of seismic micro-tremors, carried out before and after the installation of the piles, has been evaluated the modification of the resonance frequency of the site, and modification of the propagation speed of the shear waves Vs induced by the slab over rafted piles over the entire area.