Characterization of the geomechanical behavior of the seabed along a high-pressure high-temperature (HPHT) pipeline route is important for understanding risks from geohazards and thermally induced displacements such as axial walking. Axial resistance to pipeline displacement, from the friction between seabed and the contact surface of the pipe, can be estimated through laboratory tests using interface shear box (ISB) and tilt table. Tests performed by NGI in several developements in Gulf of Mexico, South America, and West Africa revealed significant variation in shear resistance, potentially associated with the type of interface material and surface roughness characteristics. This paper illustrates the effect of clay activity and interface surface material on the residual undrained interface strength estimated from interface shear box tests. Two cohesive soil batch samples with varying activity were tested using two different interface plates (steel and silicon carbide sandpaper) of comparable surface roughness. Each soil batch-interface combination was tested under three different initial effective normal stresses and two different over consolidation ratios (OCRs). Undrained residual interface strength envelopes were developed for each soil batch-interface combination. The results from tests performed on steel interface showed an increase in residual undrained interface strength with plasticy and clay activity whereas a reverse trend was observed in the results of the tests performed using the sandpaper interface. This reinforces the importance of the choice of interface plate material (in addition to surface roughness) for PSI testing program to accurately capture the resistances offered by the seabed to pipe displacement.